Article

Scaling up spatial transcriptomics for large-sized tissues: uncovering cellular-level tissue architecture beyond conventional platforms with iSCALE

2025-03-01

Abstract excerpt

Recent advances in spatial transcriptomics (ST) technologies have transformed our ability to profile gene expression while retaining the crucial spatial context within tissues. However, existing ST platforms suffer from high costs, long turnaround times, low resolution, limited gene coverage, and small tissue capture areas, which hinder their broad applications. Here we present iSCALE, a method that predicts super...

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Literature Corpus work: d1b84b57-f24f-5e97-b9dc-c3e9a794635c
DOI: 10.1101/2025.02.25.640190

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