Article
Unveiling new genetic insights in rheumatoid arthritis for drug discovery through Taxonomy3 analysis.
Scientific reports - 19 Jun 2024
Kozlowska Justyna, Humphryes-Kirilov Neil, Pavlovets Anastasia, Connolly Martin, Kuncheva Zhana, Horner Jonathan, Manso Ana Sousa, Murray Clare, Fox J Craig, McCarthy Alun
Abstract excerpt
Genetic support for a drug target has been shown to increase the probability of success in drug development, with the potential to reduce attrition in the pharmaceutical industry alongside discovering novel therapeutic targets. It is therefore important to maximise the detection of genetic associations that affect disease susceptibility. Conventional statistical methods such as genome-wide association studies...
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