Article
Optimizing oral immune tolerance to Type II collagen in patients with rheumatoid arthritis: The importance of dose, interfering medication and genetics.
The American journal of the medical sciences - 1 Oct 2024
Postlethwaite Arnold E, Jiao Yan, Yang Chengyuan, Dong Wei, Aelion Jacob A, Wang Benjamin, Postlethwaite Bennett E, Sigal Leonard, Kang Andrew H, Myers Linda K, Wheller Patricia, Ingels Jesse, Gu Weikuan
Abstract excerpt
OBJECTIVES: Oral immune tolerance (OT) is a complex process with unknown genetic regulation. Our aim is to explore possible genetic control of OT in patients with rheumatoid arthritis (RA). METHODS: RA patients with increased interferon γ production invitro when their isolated peripheral blood mononuclear cells (PBMC) were cultured with type II bovine collagen α1 chain [α1 (II)] were enrolled in this study and...
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