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An induced pluripotent stem cell line carrying a silencing-resistant calcium reporter allele.

Stem cell research - 1 Sept 2024

Durens Madel, Baljinnyam Erdene, Grisanti Laura, Hu Ruiqi, Marro Samuele G

Abstract excerpt

Calcium indicators are sensitive tools to image neural activity. However, their use in human induced pluripotent stem cells (iPSC)-derived neurons is limited by silencing of the transgene. We generated the iPSC line MSE2336A carrying heterozygous insertion in the safe-harbor locus AAVS1 of the ultrasensitive protein calcium sensor (GCaMP6) under the control of CAG promoter and UCOE to maintain robust transgene...

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PMID: 38896969
DOI: 10.1016/j.scr.2024.103455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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