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Safety concern of recombination between self-amplifying mRNA vaccines and viruses is mitigated in vivo

17 Jun 2024

Abstract excerpt

Self-amplifying mRNA (SAM) vaccines can be rapidly deployed in the event of disease outbreaks. A legitimate safety concern is the potential for recombination between alphavirus-based SAM vaccines and circulating viruses. This theoretical risk needs to be assessed in the regulatory process for SAM vaccine approval. Herein, we undertake extensive in vitro and in vivo assessments to explore recombination between SAM...

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PMID: 38894543
DOI: 10.1016/j.ymthe.2024.06.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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