Article
Genetic deletion of the circadian clock transcription factor BMAL1 and chronic alcohol consumption differentially alter hepatic glycogen in mice.
American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2018
Udoh Uduak S, Valcin Jennifer A, Swain Telisha M, Filiano Ashley N, Gamble Karen L, Young Martin E, Bailey Shannon M
Abstract excerpt
Multiple metabolic pathways exhibit time-of-day-dependent rhythms that are controlled by the molecular circadian clock. We have shown that chronic alcohol is capable of altering the molecular clock and diurnal oscillations in several elements of hepatic glycogen metabolism ( 19 , 44 ). Herein, we sought to determine whether genetic disruption of the hepatocyte clock differentially impacts hepatic glycogen content...
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