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A review on mechanism of action, resistance, synergism, and clinical implications of mupirocin against Staphylococcus aureus

26 Nov 2018

Abstract excerpt

Mupirocin (MUP), bactroban, or pseudomonic acid is a natural crotonic acid derivative drug extracted from Pseudomonas fluorescens which is produced by modular polyketide synthases. This antibiotic has a unique chemical structure and mechanism of action. It is a mixture of A-D pseudomonic acids and inhibits protein synthesis through binding to bacterial isoleucyl-tRNA synthetase. MUP is often prescribed to prevent...

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PMID: 30551435
DOI: 10.1016/j.biopha.2018.10.131

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