Multi-ancestry polygenic risk scores for venous thromboembolism.

doi:10.1093/hmg/ddae097

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Article

Multi-ancestry polygenic risk scores for venous thromboembolism.

Human molecular genetics - 3 Sept 2024

Jee Yon Ho, Thibord Florian, Dominguez Alicia, Sept Corriene, Boulier Kristin, Venkateswaran Vidhya, Ding Yi, Cherlin Tess, Verma Shefali Setia, Faro Valeria Lo, Bartz Traci M, Boland Anne, Brody Jennifer A, Deleuze Jean-Francois, Emmerich Joseph, Germain Marine, Johnson Andrew D, Kooperberg Charles, Morange Pierre-Emmanuel, Pankratz Nathan, Psaty Bruce M, Reiner Alexander P, Smadja David M, Sitlani Colleen M, Suchon Pierre, Tang Weihong, Trégouët David-Alexandre, Zöllner Sebastian, Pasaniuc Bogdan, Damrauer Scott M, Sanna Serena, Snieder Harold, Kabrhel Christopher, Smith Nicholas L, Kraft Peter

Abstract excerpt

Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality, with large disparities in incidence rates between Black and White Americans. Polygenic risk scores (PRSs) limited to variants discovered in genome-wide association studies in European-ancestry samples can identify European-ancestry individuals at high risk of VTE. However, there is limited evidence on whether high-dimensional...

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Identifiers

PMID: 38879759
DOI: 10.1093/hmg/ddae097
PMCID: PMC11373328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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