Article
Construction and optimization of a polygenic risk model for venous thromboembolism in the Chinese population.
Journal of vascular surgery. Venous and lymphatic disorders - 1 Jan 2024
Liu Chao, Hou Jiaxuan, Li Weiming, Chen Jinxing, Li Yane, Zhang Jiawei, Zhou Wei, Zhang Wei, Deng Fenni, Wang Yu, Chen Luan, Qin Shengying, Meng Xiaohong, Lu Shaoying
Abstract excerpt
BACKGROUND: Venous thromboembolism (VTE) has both environmental and genetic risk factors. It is regulated by polygenes and multisites. The polygenic risk score (PRS) has been widely used because any single genetic biomarker failed to accurately predict the genetic risk of VTE. However, no polygenic risk model has been proposed for VTE in the Chinese population. Thus, we aimed to construct a PRS model for the...
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