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Article

Harnessing Polygenic Risk Scores to Refine Venous Thromboembolism Risk Stratification.

European journal of haematology - 1 Oct 2026

McKay Katlyn G, Zhao Oliver S, Badrieh Samaya S, Bastarache Lisa, Niu Xinnan, He Jing, Kannankeril Prince J, Robinson Jamie R

Abstract excerpt

BACKGROUND: Venous thromboembolism (VTE) is a major cause of morbidity in patients of all ages. Despite growing interest in polygenic risk scores (PRS) for VTE, their utility remains understudied. Our objective was to evaluate the independent impact of a PRS on VTE susceptibility in adults and children. METHODS: We completed a retrospective, case-control study of two separate cohorts with evaluation of three VTE...

Read the complete abstract on PubMed

Topics

Humans
Venous Thromboembolism
Genetic Risk Score
Female
Polymorphism, Single Nucleotide
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Middle Aged

Risk Factors

Case-Control Studies

Child

Male

Multifactorial Inheritance

Risk Assessment

Aged

Adolescent

Retrospective Studies

Child, Preschool

Source

Open in PubMed Open full text

Identifiers

PMID: 42093615
DOI: 10.1111/ejh.70212
PMCID: PMC13160238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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