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Article

Single-housing-induced islet epigenomic changes are related to polymorphisms in diabetic KK mice.

Life science alliance - 1 Aug 2024

Nammo Takao, Funahashi Nobuaki, Udagawa Haruhide, Kozawa Junji, Nakano Kenta, Shimizu Yukiko, Okamura Tadashi, Kawaguchi Miho, Uebanso Takashi, Nishimura Wataru, Hiramoto Masaki, Shimomura Iichiro, Yasuda Kazuki

Abstract excerpt

A lack of social relationships is increasingly recognized as a type 2 diabetes (T2D) risk. To investigate the underlying mechanism, we used male KK mice, an inbred strain with spontaneous diabetes. Given the association between living alone and T2D risk in humans, we divided the non-diabetic mice into singly housed (KK-SH) and group-housed control mice. Around the onset of diabetes in KK-SH mice, we compared...

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Share to Diabetes Mellitus, Experimental
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epigenesis, Genetic

Share to Epigenomics

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Share to Islets of Langerhans

Share to Mice, Inbred C57BL

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Identifiers

PMID: 38876803
DOI: 10.26508/lsa.202302099
PMCID: PMC11178941

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