Article
Tumor cell enrichment by tissue suspension improves sensitivity to copy number variation in diffuse gastric cancer with low tumor content.
Scientific reports - 13 Jun 2024
Hatakeyama Keiichi, Muramatsu Koji, Nagashima Takeshi, Ichida Hiroyuki, Kawanishi Yuichi, Fukumura Ryutaro, Ohshima Keiichi, Shimoda Yuji, Ohnami Sumiko, Ohnami Shumpei, Maruyama Koji, Naruoka Akane, Kenmotsu Hirotsugu, Urakami Kenichi, Akiyama Yasuto, Sugino Takashi, Yamaguchi Ken
Abstract excerpt
The detection of copy number variations (CNVs) and somatic mutations in cancer is important for the selection of specific drugs for patients with cancer. In cancers with sporadic tumor cells, low tumor content prevents the accurate detection of somatic alterations using targeted sequencing. To efficiently identify CNVs, we performed tumor cell enrichment using tissue suspensions of formalin-fixed...
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