Article
Neuroblastoma susceptibility and association of N7-methylguanosine modification gene polymorphisms: multi-center case-control study.
Pediatric research - 1 Jan 2025
Lin Huiran, Liao Fan, Liu Jiabin, Yang Zhonghua, Zhang Jiao, Cheng Jiwen, Zhou Haixia, Li Suhong, Li Li, Li Yong, Zhuo Zhenjian, He Jing
Abstract excerpt
BACKGROUND: Neuroblastoma (NB) is a common extracranial solid malignancy in children. The N7-methylguanosine (m7G) modification gene METTL1/WDR4 polymorphisms may serve as promising molecular markers for identifying populations susceptible to NB. METHODS: TaqMan probes was usded to genotype METTL1/WDR4 single nucleotide polymorphisms (SNPs) in 898 NB patients and 1734 healthy controls. A logistic regression model...
Read the complete abstract on PubMedTopics
- Humans
- Polymorphism, Single Nucleotide
- Genetic Predisposition to Disease
- Case-Control Studies
- Female