Article
Association of MALAT1 gene polymorphisms with neuroblastoma susceptibility in children from Jiangsu Province.
Human genomics - 12 Dec 2025
Lian Yong, He Lili, Dong Siqi, Li Mengjia, Zhang Wenli, Zhang Mengzhen, Zhang Xinxin, Zhou Chunlei, He Jing
Abstract excerpt
BACKGROUND: Neuroblastoma, a clinically heterogeneous pediatric tumor, has varying outcomes ranging from spontaneous regression to aggressive metastasis. Recent studies have emphasized non-coding RNAs, particularly long non-coding RNAs (lncRNAs), as crucial regulators of cancer epigenetics. MALAT1 is a dual oncogenic lncRNA with some therapeutic potential but has rarely been studied in neuroblastoma. METHODS: We...
Topics
- Humans
- RNA, Long Noncoding
- Neuroblastoma
- Genetic Predisposition to Disease
- Polymorphism, Single Nucleotide
- Female
- Male
- Child
- Child, Preschool
- Infant
- Prognosis
- China
- Gene Expression Regulation, Neoplastic