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Article

Monoamine oxidase-A (MAO-A) low-expression variants and increased risk of Plasmodium vivax malaria relapses.

The Journal of antimicrobial chemotherapy - 1 Aug 2024

Puça Maria Carolina Silva De Barros, Rodrigues Danielle Fonseca, Salazar Yanka Evellyn Alves Rodrigues, Louzada Jaime, Fontes Cor Jesus Fernandes, Daher André, Pereira Dhélio Batista, Fernandes Vieira José Luiz, Carvalho Luzia Helena, Alves de Brito Cristiana Ferreira, Gil José Pedro, Nobrega de Sousa Tais

Abstract excerpt

OBJECTIVES: Primaquine is essential for the radical cure of Plasmodium vivax malaria and must be metabolized into its bioactive metabolites. Accordingly, polymorphisms in primaquine-metabolizing enzymes can impact the treatment efficacy. This pioneering study explores the influence of monoamine oxidase-A (MAO-A) on primaquine metabolism and its impact on malaria relapses. METHODS: Samples from 205 patients with...

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Share to Antimalarials
Share to Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Malaria, Vivax

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Share to Polymorphism, Genetic

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Source

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Identifiers

PMID: 38870082
DOI: 10.1093/jac/dkae196
PMCID: PMC11290872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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