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Unraveling the Impact of the PROCA1 Mutation in Male Infertility: Incorporating Whole Exome Sequencing in Teratozoospermia Patients and Analyzing Proca1 Knockout Mice.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Apr 2025

Zheng Na, Shen Yiru, Wang Yu, Xiang Mingfei, Yu Kexin, Zhang Jingjing, Zha Xiaomin, Duan Zongliu, Wang Fengsong, Zhu Fuxi, Cao Yunxia

Abstract excerpt

In the world, about 15% of couples are infertile, and nearly half of all infertility was caused by men. A large number of genetic mutations are thought to affect spermatogenesis by regulating acrosome formation. Here, we identified three patients harbouring the protein interacting with cyclin A1 (PROCA1) mutation by whole exome sequencing (WES) and Sanger sequencing among patients with predominantly...

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Identifiers

PMID: 38867036
DOI: 10.1007/s43032-024-01624-6

Genes

PROCA1

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