Article
Association between polymorphisms in TLR3, TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil.
Expert review of molecular diagnostics - 1 Jun 2024
Braga Matheus, Shiga Mariana Akemi Sonoda, Silva Pedro Emanuel Santiago, Yamanaka Aléia Harumi Uchibaba, Souza Victor Hugo, Grava Sergio, Simão Andréa Name Colado, Neves Janisleya Silva Ferreira, de Lima Neto Quirino Alves, Zacarias Joana Maira Valentini, Visentainer Jeane Eliete Laguila
Abstract excerpt
BACKGROUND: A distinct phenotype in Coronavirus disease 2019 (Covid-19) was observed in severe patients, consisting of a highly impaired interferon (IFN) type I response, an exacerbated inflammatory response. OBJECTIVE: The aim of the present study was to investigate a possible association of sin...
Topics
- Adult
- Aged
- Female
- Humans
- Male
- Middle Aged
- Brazil
- COVID-19
- Cross-Sectional Studies
- Genetic Predisposition to Disease
- Genotype
- Interferon Type I
- Interferon-alpha
- Polymorphism, Single Nucleotide