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Article

Association between Interferon-Lambda-3 rs12979860, TLL1 rs17047200 and DDR1 rs4618569 Variant Polymorphisms with the Course and Outcome of SARS-CoV-2 Patients.

Genes - 28 May 2021

Agwa Sara H A, Kamel Marwa Mostafa, Elghazaly Hesham, Abd Elsamee Aya M, Hafez Hala, Girgis Samia Abdo, Ezz Elarab Hoda, Ebeid Fatma S E, Sayed Safa Matbouly, Sherif Lina, Matboli Marwa

Abstract excerpt

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection provides a critical host-immunological challenge. AIM: We explore the effect of host-genetic variation in interferon-lambda-3 rs12979860, Tolloid Like-1 (TLL1) rs17047200 and Discoidin domain receptor 1(DDR1) rs4618569 on host response to respiratory viral infections and disease severity that may probe the mechanistic approach of...

Topics

Alleles
Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

COVID-19

Case-Control Studies

Comorbidity

Cytokines

Discoidin Domain Receptor 1

Female

Genetic Predisposition to Disease

Genotype

Host-Pathogen Interactions

Humans

Immunity, Innate

Interferons

Male

Polymorphism, Single Nucleotide

Prognosis

SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 34071309
DOI: 10.3390/genes12060830
PMCID: PMC8230293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-34071309-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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