Article
Lionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload.
Communications biology - 13 Aug 2020
Kuwabara Yasuhide, Tsuji Shuhei, Nishiga Masataka, Izuhara Masayasu, Ito Shinji, Nagao Kazuya, Horie Takahiro, Watanabe Shin, Koyama Satoshi, Kiryu Hisanori, Nakashima Yasuhiro, Baba Osamu, Nakao Tetsushi, Nishino Tomohiro, Sowa Naoya, Miyasaka Yui, Hatani Takeshi, Ide Yuya, Nakazeki Fumiko, Kimura Masahiro, Yoshida Yoshinori, Inada Tsukasa, Kimura Takeshi, Ono Koh
Abstract excerpt
Recent high-throughput approaches have revealed a vast number of transcripts with unknown functions. Many of these transcripts are long noncoding RNAs (lncRNAs), and intergenic region-derived lncRNAs are classified as long intergenic noncoding RNAs (lincRNAs). Although Myosin heavy chain 6 (Myh6) encoding primary contractile protein is down-regulated in stressed hearts, the underlying mechanisms are not fully...
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