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Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes.

Scientific reports - 11 Jun 2024

Antikainen Anni A, Haukka Jani K, Kumar Anmol, Syreeni Anna, Hägg-Holmberg Stefanie, Ylinen Anni, Kilpeläinen Elina, Kytölä Anastasia, Palotie Aarno, Putaala Jukka, Thorn Lena M, Harjutsalo Valma, Groop Per-Henrik, Sandholm Niina

Abstract excerpt

Individuals with type 1 diabetes (T1D) carry a markedly increased risk of stroke, with distinct clinical and neuroimaging characteristics as compared to those without diabetes. Using whole-exome or whole-genome sequencing of 1,051 individuals with T1D, we aimed to find rare and low-frequency genomic variants associated with stroke in T1D. We analysed the genome comprehensively with single-variant analyses, gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38862513
DOI: 10.1038/s41598-024-61840-7
PMCID: PMC11166668

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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