Article
Loss-of-function polymorphisms in NQO1 are not associated with the development of subacute myelo-optico-neuropathy.
Molecular genetics & genomic medicine - 1 Jun 2024
Matsumoto Hideki, Sasai Hideo, Kawamoto Norio, Katsuyama Masato, Minamiyama Makoto, Kuru Satoshi, Fukao Toshiyuki, Ohnishi Hidenori
Abstract excerpt
BACKGROUND: Subacute myelo-optico-neuropathy (SMON) is a neurological disorder associated with the administration of clioquinol, particularly at very high doses. Although clioquinol has been used worldwide, there was an outbreak of SMON in the 1950s-1970s in which the majority of cases were in Japan, prompting speculation that the unique genetic background of the Japanese population may have contributed to the...
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