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ABCB1 c.3435C > T and EPHX1 c.416A > G polymorphisms influence plasma carbamazepine concentration, metabolism, and pharmacoresistance in epileptic patients.

Gene - 30 Dec 2021

Zhang Ming-Liang, Chen Xiao-Long, Bai Zhao-Fang, Zhao Xu, Li Wei-Xia, Wang Xiao-Yan, Zhang Hui, Chen Xiao-Fei, Zhang Shu-Qi, Tang Jin-Fa, Xiao Xiao-He, Zhao Yan-Ling

Abstract excerpt

The gene polymorphisms of ABCB1, EPHX1, and SCN1A were found to influence carbamazepine (CBZ) metabolism and resistance in epilepsy patients, but the relevance remains controversial. To reveal the relationships among the gene polymorphisms of ABCB1, EPHX1, SCN1A and the metabolism and resistance of CBZ, the databases of PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, Chinese Science...

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Identifiers

PMID: 34411648
DOI: 10.1016/j.gene.2021.145907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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