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Article

Genome-wide DNA methylation in relation to ARID1A deficiency in ovarian clear cell carcinoma.

Journal of translational medicine - 10 Jun 2024

Li Shang, Meersma Gert Jan, Kupryjanczyk Jolanta, de Jong Steven, Wisman G Bea A

Abstract excerpt

BACKGROUND: The poor chemo-response and high DNA methylation of ovarian clear cell carcinoma (OCCC) have attracted extensive attentions. Recently, we revealed the mutational landscape of the human kinome and additional cancer-related genes and found deleterious mutations in ARID1A, a component of the SWI/SNF chromatin-remodeling complex, in 46% of OCCC patients. The present study aims to comprehensively...

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Topics

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Share to Adenocarcinoma, Clear Cell
Share to Cluster Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Genome, Human

Share to Nuclear Proteins

Share to Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 38858765
DOI: 10.1186/s12967-024-05311-7
PMCID: PMC11163774

Genes

ARID1A
IRX1
PIK3CA
TMEM101
TP53
TRIP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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