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Article

Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.

Science translational medicine - 3 Jan 2024

Wheeler Emily C, Martin Benjamin J E, Doyle William C, Neaher Sofia, Conway Caroline A, Pitton Caroline N, Gorelov Rebecca A, Donahue Melanie, Jann Johann C, Abdel-Wahab Omar, Taylor Justin, Seiler Michael, Buonamici Silvia, Pikman Yana, Garcia Jacqueline S, Belizaire Roger, Adelman Karen, Tothova Zuzana

Abstract excerpt

Splicing modulation is a promising treatment strategy pursued to date only in splicing factor-mutant cancers; however, its therapeutic potential is poorly understood outside of this context. Like splicing factors, genes encoding components of the cohesin complex are frequently mutated in cancer, including myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (AML), where they are associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 38170787
DOI: 10.1126/scitranslmed.ade2774
PMCID: PMC11222919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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