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[Somatic JAK2 gene mutation is an evolving risk factor in cardiovascular diseases].

Orvosi hetilap - 9 Jun 2024

Magyar Eszter, Újfalusi Anikó, Czenke Marianna, Méhes Gábor

Abstract excerpt

A JAK-kináz működése egyes, sejtfelszíni receptorokhoz kötött jelátviteli útvonalak központi eleme (JAK/STAT útvonal), a fiziológiás sejtaktiváció közvetítője. Közvetítő hatása a myeloid eredetű sejtekben, elsősorban macrophagokban, neutrophil granulocytákban, illetve a thrombocytákban is szükséges a nem specifikus gyulladásos reakció elindításához. A jelátviteli útvonal kóros aktivációja a krónikus...

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Identifiers

PMID: 38852144
DOI: 10.1556/650.2024.33055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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