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Article

Somatic Variants Acquired Later in Life Associated with Thoracic Aortic Aneurysms: JAK2 V617F.

Genes - 5 Jul 2024

Waldron Christina, Zafar Mohammad A, Ma Deqiong, Zhang Hui, Dykas Daniel, Ziganshin Bulat A, Popa Andreea, Jha Alokkumar, Kwan Jennifer M, Elefteriades John A

Abstract excerpt

The JAK2 V617F somatic variant is a well-known driver of myeloproliferative neoplasms (MPN) associated with an increased risk for athero-thrombotic cardiovascular disease. Recent studies have demonstrated its role in the development of thoracic aortic aneurysm (TAA). However, limited clinical information and level of JAK2 V617F burden have been provided for a comprehensive evaluation of potential confounders. A...

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Identifiers

PMID: 39062663
DOI: 10.3390/genes15070883
PMCID: PMC11276600

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