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Article

Somatic Mutations in Cardiovascular Disease.

Circulation research - 7 Jan 2022

Heimlich J Brett, Bick Alexander G

Abstract excerpt

Advances in population-scale genomic sequencing have greatly expanded the understanding of the inherited basis of cardiovascular disease (CVD). Reanalysis of these genomic datasets identified an unexpected risk factor for CVD, somatically acquired DNA mutations. In this review, we provide an overview of somatic mutations and their contributions to CVD. We focus on the most common and well-described manifestation,...

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Identifiers

PMID: 34995138
DOI: 10.1161/CIRCRESAHA.121.319809
PMCID: PMC8827644

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