Article
Association of promoter region single nucleotide polymorphisms at positions -819C/T and -592C/A of interleukin 10 gene with ischemic heart disease.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Aug 2012
Yu Gyeong-Im, Cho Ho-Chan, Cho Yun-Kyeong, Park Hyoung-Seob, Yoon Hyuck-Jun, Kim Hyung-Seop, Nam Chang-Wook, Kim Yoon-Nyun, Kim Kwon-Bae, Ha Eunyoung, Shin Dong-Hoon, Hur Seung-Ho
Abstract excerpt
OBJECTIVE: Ischemic heart disease (IHD) is a disease characterized by ischemia of the heart muscle, usually due to coronary artery disease. Interleukin-10 (IL10) is a proinflammatory cytokine known to protect endothelial function. In this study, we investigated the association of promoter region polymorphisms of the IL10 gene with IHD. METHODS: We recruited 313 control and 173 IHD patients. The selected SNPs in...
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