Article
High hyperdiploid karyotype with ≥ 49 chromosomes represents a heterogeneous subgroup of acute myeloid leukemia with differential TP53 mutation status and prognosis: a single-center study from China.
Annals of hematology - 1 Jul 2024
Zhang Zhiyu, Fu Chunmei, Sun Yingxin, Liu Yizi, Wang Qian, Yan Wanhui, Wu Chunxiao, Wang Qingrong, Zeng Zhao, Wen Lijun, Shen Hongjie, Yao Li, Liu Dandan, Chen Suning, Pan Jinlan
Abstract excerpt
High hyperdiploid karyotype with ≥ 49 chromosomes (which will be referred to as HHK) is rare in acute myeloid leukemia (AML). The European leukemia network (ELN) excluded those harboring only numerical changes (with ≥ 3 chromosome gains) from CK and listed them in the intermediate risk group, while the UK National Cancer Research Institute Adult Leukaemia Working Group classification defined ≥ 4 unrelated...
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