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Article

Epigenetic predictors of species maximum life span and other life-history traits in mammals

7 Jun 2024

Abstract excerpt

By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation (DNAm) predictors of maximum life span ( R = 0.89), gestation time ( R = 0.96), and age at sexual maturity ( R = 0.85). Our maximum life-span predictor indicates a potential innate longevity advantage for females over males in 17 mammalian species including humans. The DNAm maximum life-span predictions are not affected by caloric...

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PMID: 38848365
DOI: 10.1126/sciadv.adm7273

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