Article

Aging at scale: Younger dogs and larger breeds from the Dog Aging Project show accelerated epigenetic aging

2024-10-04

Abstract excerpt

Dogs exhibit striking within-species variability in lifespan, with smaller breeds often living more than twice as long as larger breeds. This longevity discrepancy also extends to health and aging–larger dogs show higher rates of age-related diseases. Despite this well-established phenomenon, we still know little about the biomarkers and molecular mechanisms that might underlie breed differences in aging and survi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4d0173a-b986-51ed-a782-17ff98389ab0
DOI: 10.1101/2024.10.03.616519

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aging at scale: Younger dogs and larger breeds from the Dog Aging Project show accelerated epigenetic agingDOI 10.1101/2024.10.03.616519Read

Epigenetic clock and methylation studies in dogsSemantic proximity Read

Quantitative translation of dog-to-human aging by conserved remodeling of epigenetic networksSemantic proximity Read

DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging ProjectSemantic proximity Read

A revisiting of "the hallmarks of aging" in domestic dogs: current status of the literature.Semantic proximity Read

Blood biomarkers and breed genetics of aging in pet dogsSemantic proximity Read

Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian speciesSemantic proximity Read

The phenotype of aging in the dog: how aging impacts the health and well-being of dogs and their caregivers.Semantic proximity Read

DNA methylation markers of age(ing) in non‐model animalsSemantic proximity Read

DNA methylation clocks show slower progression of aging in naked mole-rat queensSemantic proximity Read

The effects of age, sex, weight, and breed on canid methylomes.Semantic proximity Read

Universal DNA methylation age across mammalian tissuesSemantic proximity Read

Dogs and humans share biomarkers of mortalitySemantic proximity Read