Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species

Abstract excerpt

BACKGROUND: Mammalian species exhibit a wide range of lifespans. To date, a robust and dynamic molecular readout of these lifespan differences has not yet been identified. Recent studies have established the existence of ageing-associated differentially methylated positions (aDMPs) in human and mouse. These are CpG sites at which DNA methylation dynamics show significant correlations with age. We hypothesise that...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Epigenetics and DNA Methylation
• Share to Genetics, Aging, and Longevity in Model Organisms
• Share to Telomeres, Telomerase, and Senescence