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Article

Understanding variants of unknown significance: the computational frontier.

The oncologist - 5 Aug 2024

Fu Xi, Rabadan Raul

Abstract excerpt

The rapid advancement of sequencing technologies has led to the identification of numerous mutations in cancer genomes, many of which are variants of unknown significance (VUS). Computational models are increasingly being used to predict the functional impact of these mutations, in both coding and noncoding regions. Integration of these models with emerging genomic datasets will refine our understanding of...

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PMID: 38848164
DOI: 10.1093/oncolo/oyae103
PMCID: PMC11299926

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