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Article

Epigenetic alterations in preeclampsia: a focus on microRNA149 and tetrahydrofolate reductase gene polymorphisms in Egyptian women.

Irish journal of medical science - 1 Oct 2024

Ellakwa Doha El-Sayed, Rashed Laila Ahmed, El-Mandoury Ahmed Abdel-Aziz, Younis Naglaa Feisal

Abstract excerpt

BACKGROUND: Preeclampsia (PE) poses a substantial risk to prenatal and maternal health. Folic acid (FA) and methylenetetrahydrofolate reductase (MTHFR) play roles in DNA methylation and genomic integrity maintenance, with MTHFR polymorphisms potentially impacting PE occurrence. Human microRNA 149 (miR-149) remains underexplored in PE despite its involvement in folate metabolism. This study seeks to evaluate serum...

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PMID: 38848035
DOI: 10.1007/s11845-024-03732-3

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