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Burkholderia pseudomallei BipD modulates host mitophagy to evade killing

4 Jun 2024

Abstract excerpt

Mitophagy is critical for mitochondrial quality control and function to clear damaged mitochondria. Here, we found that Burkholderia pseudomallei maneuvered host mitophagy for its intracellular survival through the type III secretion system needle tip protein BipD. We identified BipD, interacting with BTB-containing proteins KLHL9 and KLHL13 by binding to the Back and Kelch domains, recruited NEDD8 family RING E3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38834545
DOI: 10.1038/s41467-024-48824-x

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