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Article

POLM variant G312R promotes ovarian tumorigenesis through genomic instability and COL11A1-NF-κB axis.

American journal of physiology. Cell physiology - 1 Jul 2024

Xiao Yue, Ni Maowei, Zheng Zhiguo, Liu Yufeng, Yin Mingyu, Mao Shuyu, Zhao Ye, Tian Bing, Wang Liangyan, Xu Hong, Hua Yuejin

Abstract excerpt

In ovarian cancer (OC), identifying key molecular players in disease escalation and chemoresistance remains critical. Our investigation elucidates the role of the DNA polymerase mu (POLM), especially G312R mutation, in propelling oncogenesis through dual pathways. POLMG312R markedly augments the ribonucleotide insertion capability of POLM, precipitating genomic instability. In addition, our research reveals that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38826139
DOI: 10.1152/ajpcell.00025.2024

Genes

POLM
COL11A1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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