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Article

LINC01116-dependent upregulation of RNA polymerase I transcription drives oncogenic phenotypes in lung adenocarcinoma.

Journal of translational medicine - 5 Oct 2024

Sarkar Shashanka Shekhar, Sharma Mansi, Saproo Sheetanshu, Naidu Srivatsava

Abstract excerpt

BACKGROUND: Hyperactive RNA Polymerase I (Pol I) transcription is canonical in cancer, associated with malignant proliferation, poor prognosis, epithelial-mesenchymal transition, and chemotherapy resistance. Despite its significance, the molecular mechanisms underlying Pol I hyperactivity remain unclear. This study aims to elucidate the role of long noncoding RNAs (lncRNAs) in regulating Pol I transcription in...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39369230
DOI: 10.1186/s12967-024-05715-5
PMCID: PMC11453068

Genes

TAF1A
TAF1D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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