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Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects

14 Feb 2017

Abstract excerpt

BACKGROUND: Human skeletal muscle stem cells are important for muscle regeneration. However, the combined genome-wide DNA methylation and expression changes taking place during adult myogenesis have not been described in detail and novel myogenic factors may be discovered. Additionally, obesity is associated with low relative muscle mass and diminished metabolism. Epigenetic alterations taking place during...

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PMID: 28222718
DOI: 10.1186/s12916-017-0792-x

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