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Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming

6 Sept 2020

Abstract excerpt

Obesity promotes dysfunction and impairs the reparative capacity of mesenchymal stem/stromal cells (MSCs), and alters their transcription, protein content, and paracrine function. Whether these adverse effects are mediated by chromatin-modifying epigenetic changes remains unclear. We tested the hypothesis that obesity imposes global DNA hydroxymethylation and histone tri-methylation alterations in obese swine...

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PMID: 32893712
DOI: 10.1080/15592294.2020.1819663

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