Anhedonia as a Potential Transdiagnostic Phenotype With Immune-Related Changes in Recent-Onset Mental Health Disorders.

doi:10.1016/j.biopsych.2024.05.019

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Article

Anhedonia as a Potential Transdiagnostic Phenotype With Immune-Related Changes in Recent-Onset Mental Health Disorders.

Biological psychiatry - 1 Oct 2024

Lalousis Paris Alexandros, Malaviya Aanya, Khatibi Ali, Saberi Majid, Kambeitz-Ilankovic Lana, Haas Shalaila S, Wood Stephen J, Barnes Nicholas M, Rogers Jack, Chisholm Katharine, Bertolino Alessandro, Borgwardt Stefan, Brambilla Paolo, Kambeitz Joseph, Lencer Rebekka, Pantelis Christos, Ruhrmann Stephan, Salokangas Raimo K R, Schultze-Lutter Frauke, Schmidt Andre, Meisenzahl Eva, Dwyer Dominic, Koutsouleris Nikolaos, Upthegrove Rachel, Griffiths Siân Lowri

Abstract excerpt

BACKGROUND: Chronic low-grade inflammation is observed across mental disorders and is associated with difficult-to-treat-symptoms of anhedonia and functional brain changes, reflecting a potential transdiagnostic dimension. Previous investigations have focused on distinct illness categories in people with enduring illness, but few have explored inflammatory changes. We sought to identify an inflammatory signal and...

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PMID: 38823495
DOI: 10.1016/j.biopsych.2024.05.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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