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Construction of Vero cell-adapted rabies vaccine strain by five amino acid substitutions in HEP-Flury strain

31 May 2024

Abstract excerpt

Rabies virus (RABV) causes fatal neurological disease. Pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) using inactivated-virus vaccines are the most effective measures to prevent rabies. In Japan, HEP-Flury, the viral strain, used as a human rabies vaccine, has historically been propagated in primary fibroblast cells derived from chicken embryos. In the present study, to reduce the cost and...

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PMID: 38822013
DOI: 10.1038/s41598-024-63337-9

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