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Article

The causal effect of folate on major depressive disorder: Mendelian randomization, LDSC, and colocalization analysis.

Medicine - 21 Nov 2025

Liu Dele, Liao Fengxiang, Xiong Yanping, Huang Zizhen

Abstract excerpt

Dietary intervention is beneficial in reducing the risk of major depressive disorder (MDD). Nevertheless, whether the intake of macronutrients and vitamin B supplements is causally associated with MDD remains unclear. Univariate Mendelian randomization was performed to identify the causal effect of the relative intake of macronutrients (including fat, protein, and carbohydrates) and vitamin B (including vitamin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41305750
DOI: 10.1097/MD.0000000000046149
PMCID: PMC12643625

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