Article
DDX43 promoter is frequently hypomethylated and may predict a favorable outcome in acute myeloid leukemia.
Leukemia research - 1 May 2014
Lin Jiang, Chen Qin, Yang Jing, Qian Jun, Deng Zhao-qun, Qian Wei, Chen Xing-xing, Ma Ji-chun, Xiong Dong-sheng, Ma Yu-juan, An Cui, Tang Chun-yan
Abstract excerpt
DEAD box polypeptide 43 (DDX43), a cancer/testis antigen (CTA), has been found to be overexpressed in various solid tumors and some hematologic malignancies. In the present work hypomethylation of the DDX43 gene was detected in 15% (32/214) of primary acute myeloid leukemia (AML) using real-time quantitative methylation-specific PCR (RQ-MSP). The level of DDX43 expression was correlated with DDX43 hypomethylation...
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