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Article

Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish.

Communications biology - 28 May 2024

Lai Shaohong, Shiraishi Hiroshi, Sebastian Wulan Apridita, Shimizu Nobuyuki, Umeda Ryohei, Ikeuchi Mayo, Kiyota Kyoko, Takeno Takashi, Miyazaki Shuya, Yano Shinji, Shimada Tatsuo, Yoshimura Akihiko, Hanada Reiko, Hanada Toshikatsu

Abstract excerpt

SMG9 is an essential component of the nonsense-mediated mRNA decay (NMD) machinery, a quality control mechanism that selectively degrades aberrant transcripts. Mutations in SMG9 are associated with heart and brain malformation syndrome (HBMS). However, the molecular mechanism underlying HBMS remains unclear. We generated smg9 mutant zebrafish (smg9oi7/oi7) that have a lifespan of approximately 6 months or longer,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38806677
DOI: 10.1038/s42003-024-06356-6
PMCID: PMC11133409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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