Article
Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias.
Circulation. Genomic and precision medicine - 1 Jun 2024
Weng Lu-Chen, Khurshid Shaan, Hall Amelia Weber, Nauffal Victor, Morrill Valerie N, Sun Yan V, Rämö Joel T, Beer Dominik, Lee Simon, Nadkarni Girish, Johnson Renee, Andreasen Laura, Clayton Anne, Pullinger Clive R, Yoneda Zachary T, Friedman Daniel J, Hyman Matthew C, Judy Renae L, Skanes Allan C, Orland Kate M, Jordà Paloma, Treu Timothy M, Oetjens Matthew T, Subbiah Rajesh, Hartmann Jacob P, May Heidi T, Kane John P, Issa Tariq Z, Nafissi Navid A, Leong-Sit Peter, Dubé Marie-Pierre, Roselli Carolina, Choi Seung Hoan, Tardif Jean-Claude, Khan Habib R, Knight Stacey, Svendsen Jesper H, Walker Bruce, Karlsson Linnér Richard, Gaziano J Michael, Tadros Rafik, Fatkin Diane, Rader Daniel J, Shah Svati H, Roden Dan M, Marcus Gregory M, Loos Ruth J F, Damrauer Scott M, Haggerty Christopher M, Cho Kelly, Palotie Aarno, Olesen Morten S, Eckhardt Lee L, Roberts Jason D, Cutler Michael J, Shoemaker M Benjamin, Wilson Peter W F, Ellinor Patrick T, Lubitz Steven A
Abstract excerpt
BACKGROUND: Substantial data support a heritable basis for supraventricular tachycardias, but the genetic determinants and molecular mechanisms of these arrhythmias are poorly understood. We sought to identify genetic loci associated with atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular accessory pathways or atrioventricular reciprocating tachycardia (AVAPs/AVRT). METHODS: We performed...
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