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Differences in p53 status significantly influence the cellular response and cell survival to 1,25-dihydroxyvitamin D3-metformin cotreatment in colorectal cancer cells.

Molecular carcinogenesis - 1 Nov 2017

Abu El Maaty Mohamed A, Strassburger Wendy, Qaiser Tooba, Dabiri Yasamin, Wölfl Stefan

Abstract excerpt

Mutations in the tumor suppressor p53 are highly prevalent in cancers and are known to influence the sensitivity of cells to various chemotherapeutics including the anti-cancer candidates 1,25-dihydrovitamin D3 [1,25D3] and metformin. Previous studies have demonstrated additive/synergistic anti-cancer effects of the 1,25D3-metformin combination in different models, however, the influence of p53 status on the...

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PMID: 28618116
DOI: 10.1002/mc.22696

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