Article
Host obesity impacts genetic variation in influenza A viral populations.
Journal of virology - 13 Jun 2024
Knoll Marissa, Honce Rebekah, Meliopoulos Victoria, Segredo-Otero Ernesto Alejandro, Johnson Katherine E E, Schultz-Cherry Stacey, Ghedin Elodie, Gresham David
Abstract excerpt
Obesity is well established as a risk factor for many noncommunicable diseases; however, its consequences for infectious disease are poorly understood. Here, we investigated the impact of host obesity on influenza A virus (IAV) genetic variation using a diet-induced obesity ferret model and the A/Hong Kong/1073/1999 (H9N2) strain. Using a co-caging study design, we investigated the maintenance, generation, and...
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