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Article

Obesity-Related Microenvironment Promotes Emergence of Virulent Influenza Virus Strains.

mBio - 3 Mar 2020

Honce Rebekah, Karlsson Erik A, Wohlgemuth Nicholas, Estrada Leonardo D, Meliopoulos Victoria A, Yao Jiangwei, Schultz-Cherry Stacey

Abstract excerpt

Obesity is associated with increased disease severity, elevated viral titers in exhaled breath, and significantly prolonged viral shed during influenza A virus infection. Due to the mutable nature of RNA viruses, we questioned whether obesity could also influence influenza virus population diversity. Here, we show that minor variants rapidly emerge in obese mice. The variants exhibit increased viral replication,...

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Identifiers

PMID: 32127459
DOI: 10.1128/mBio.03341-19
PMCID: PMC7064783

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