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Article

Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks.

Nature communications - 14 Jun 2022

Amato Katherine A, Haddock Luis A, Braun Katarina M, Meliopoulos Victoria, Livingston Brandi, Honce Rebekah, Schaack Grace A, Boehm Emma, Higgins Christina A, Barry Gabrielle L, Koelle Katia, Schultz-Cherry Stacey, Friedrich Thomas C, Mehle Andrew

Abstract excerpt

Transmission of influenza A viruses (IAV) between hosts is subject to numerous physical and biological barriers that impose genetic bottlenecks, constraining viral diversity and adaptation. The bottlenecks within hosts and their potential impacts on evolutionary pathways taken during infection are poorly understood. To address this, we created highly diverse IAV libraries bearing molecular barcodes on two gene...

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PMID: 35701424
DOI: 10.1038/s41467-022-31147-0
PMCID: PMC9197827

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