Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype.

doi:10.1007/s10456-024-09921-z

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype.

Angiogenesis - 1 Aug 2024

Rademakers Timo, Manca Marco, Jin Han, Orban Tanguy, Perisic Ljubica Matic, Frissen Hubertus J M, Rühle Frank, Hautvast Petra, van Rijssel Jos, van Kuijk Kim, Mees Barend M E, Peutz-Kootstra Carine J, Heeneman Sylvia, Daemen Mat J A P, Pasterkamp Gerard, Stoll Monika, van Zandvoort Marc A M J, Hedin Ulf, Dequiedt Franck, van Buul Jaap D, Sluimer Judith C, Biessen Erik A L

Abstract excerpt

The presence of atherosclerotic plaque vessels is a critical factor in plaque destabilization. This may be attributable to the leaky phenotype of these microvessels, although direct proof for this notion is lacking. In this study, we investigated molecular and cellular patterns of stable and hemorrhaged human plaque to identify novel drivers of intraplaque vessel dysfunction. From transcriptome data of a human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capillary Permeability

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Human Umbilical Vein Endothelial Cells

Share to Microvessels

Share to Phenotype

Share to Plaque, Atherosclerotic

Share to Spectrin

Share to Transcriptome

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 38780883
DOI: 10.1007/s10456-024-09921-z
PMCID: PMC11303431

Genes

SPTBN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype.PMID 38780883Read ↗

Encompassing view of spatial and single-cell RNA-seq renews the role of the microvasculature in human atherosclerosisSemantic proximity Read ↗

Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteriesSemantic proximity Read ↗

Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammationSemantic proximity Read ↗

Atherosclerotic plaque iron accumulation characterizes a distinct phase of intra-plaque haemorrhage and is associated with inflammation and remodellingSemantic proximity Read ↗

Transcriptomic-based clustering of advanced atherosclerotic plaques identifies subgroups of plaques with differential underlying biology that associate with clinical presentationSemantic proximity Read ↗

The thrombospondins.Semantic proximity Read ↗

Spatial Gene Expression of Human Coronary Arteries Revealed the Molecular Features of Diffuse Intimal Thickening in Explanted HeartsSemantic proximity Read ↗

Spatial gene expression of human coronary arteries revealed the molecular features of diffuse intimal thickening in explanted heartsSemantic proximity Read ↗

Endothelial cell heterogeneity.Semantic proximity Read ↗

Spatial Transcriptomic Approach to Understanding Coronary Atherosclerotic Plaque StabilitySemantic proximity Read ↗

In the balance: how do thrombospondins contribute to the cellular pathophysiology of cardiovascular disease?Semantic proximity Read ↗

A Novel Mouse Model of Atherosclerotic Plaque Instability for Drug Testing and Mechanistic/Therapeutic Discoveries Using Gene and MicroRNA Expression ProfilingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.